DegronMD

Uniprot ID: Q96BT3

Source protein: Centromere protein T

Source gene: CENPT

Class: DEG_APCC_DBOX_1

Location: 86:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7035

ASA_SCORE: 77.1

COIL: 0.4091

CONS_SCORE: 0.6702

DSS_SCORE: 0.4296

HELIX: 0.5352

FCONS_SCORE: 1.4093

RIG_SCORE: 0.8168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L103M	TCGA-D3-A3CE	SKCM	TCGA	PRTLLKNIL	DEG_APCC_DBOX_1	0.0833
p.L103M	DO37405	SKCM	ICGC	PRTLLKNIL	DEG_APCC_DBOX_1	0.0833
p.A97S	TCGA-EE-A20F	SKCM	TCGA	PRTLLKNIL	DEG_APCC_DBOX_1	0.25
p.A97S	DO37961	SKCM	ICGC	PRTLLKNIL	DEG_APCC_DBOX_1	0.25
p.N92S	TCGA-EE-A2MS	SKCM	TCGA	PRTLLKNIL	DEG_APCC_DBOX_1	0.5958
p.N92S	DO37567	SKCM	ICGC	PRTLLKNIL	DEG_APCC_DBOX_1	0.5958
p.G79V	SIDM00789	Colorectal Carcinoma	GDSC	PRTLLKNIL	DEG_APCC_DBOX_1	0.1389
p.G79V	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTLLKNIL	DEG_APCC_DBOX_1	0.1389
p.G79V	HCT-15	large_intestine	COSMIC	PRTLLKNIL	DEG_APCC_DBOX_1	0.1389
p.H80R	SIDM00918	Ovarian Carcinoma	GDSC	PRTLLKNIL	DEG_APCC_DBOX_1	0.1667
p.H80R	ACH-000103	Ovarian Cancer	CCLE	PRTLLKNIL	DEG_APCC_DBOX_1	0.1667
p.H80R	Caov-4	ovary	COSMIC	PRTLLKNIL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BT3	Centromere protein T	DEG_APCC_DBOX_1	86:94	PRTLLKNIL	APC,CDC20,FZR1	0.7035	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons