DegronMD - Q96BT3(CENPT)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L103M	TCGA-D3-A3CE	SKCM	TCGA	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0833
p.L103M	DO37405	SKCM	ICGC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0833
p.A97S	TCGA-EE-A20F	SKCM	TCGA	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.25
p.A97S	DO37961	SKCM	ICGC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.25
p.N92S	TCGA-EE-A2MS	SKCM	TCGA	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5958
p.N92S	DO37567	SKCM	ICGC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5958
p.R13S	DO229035	LICA	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation altering degron motif	0.7427
p.P25Q	DO229037	LICA	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation rewiring degron network	0.1944
p.R13H	DO23102	LINC	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation altering degron motif	0.8244
p.T14M	DO46691	PACA	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation altering degron motif	0.6312
p.A23T	SIDM00845	Burkitt's Lymphoma	GDSC	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation rewiring degron network	0.25
p.A23T	SIDM00254	Neuroblastoma	GDSC	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation rewiring degron network	0.25
p.G79V	SIDM00789	Colorectal Carcinoma	GDSC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1389
p.G79V	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1389
p.G79V	HCT-15	large intestine	COSMIC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1389
p.H80R	SIDM00918	Ovarian Carcinoma	GDSC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1667
p.H80R	ACH-000103	Ovarian Cancer	CCLE	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1667
p.H80R	Caov-4	ovary	COSMIC	PRTLLKNIL	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1667
p.D3G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRTLLRRVL	DEG_APCC_DBOX_1	12:20	Mutation rewiring degron network	0.0833

Kaplan plot for CENPT in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPT

UniProt ID: Q96BT3

Entrez ID: 80152

Protein name: Centromere protein T (CENP-T) (Interphase centromere complex protein 22)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CENPT in