DegronMD

Uniprot ID: Q96BT3

Source protein: Centromere protein T

Source gene: CENPT

Class: DEG_APCC_DBOX_1

Location: 12:20

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9912

ASA_SCORE: 69.7333

COIL: 0.2591

CONS_SCORE: 0.5666

DSS_SCORE: 0.69

HELIX: 0.7107

FCONS_SCORE: 1.2235

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R13S	DO229035	LICA	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	0.7427
p.P25Q	DO229037	LICA	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	0.1944
p.R13H	DO23102	LINC	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	0.8244
p.T14M	DO46691	PACA	ICGC	PRTLLRRVL	DEG_APCC_DBOX_1	0.6312
p.A23T	SIDM00845	Burkitt's Lymphoma	GDSC	PRTLLRRVL	DEG_APCC_DBOX_1	0.25
p.A23T	SIDM00254	Neuroblastoma	GDSC	PRTLLRRVL	DEG_APCC_DBOX_1	0.25
p.D3G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRTLLRRVL	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BT3	Centromere protein T	DEG_APCC_DBOX_1	12:20	PRTLLRRVL	APC,CDC20,FZR1	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons