DegronMD

Uniprot ID: P02686

Source protein: Myelin basic protein

Source gene: MBP

Class: DEG_SCF_FBW7_1

Location: 230:236

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 95.5429

COIL: 0.9677

CONS_SCORE: 0.4552

DSS_SCORE: 0.6499

HELIX: 0.0163

FCONS_SCORE: 0.9424

RIG_SCORE: 0.6583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R228H	ACH-000952	Prostate Cancer	CCLE	PRTPPPS	DEG_SCF_FBW7_1	0.2778
p.P235L	KP-N-YS	autonomic_ganglia	COSMIC	PRTPPPS	DEG_SCF_FBW7_1	0.6471
p.P235L	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPPPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02686	Myelin basic protein	DEG_SCF_FBW7_1	230:236	PRTPPPS	FBXW7	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons