DegronMD - P02686(MBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R88H	TCGA-A5-A0G1	UCEC	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8244
p.R88H	DO23206	LINC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8244
p.R88H	DO42472	UCEC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8244
p.R88H	SIDM00777	Colorectal Carcinoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8244
p.R88H	ACH-000360	Colon/Colorectal Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8244
p.R88H	NCI-H508	large intestine	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8244
p.N85S	TCGA-BH-A18G	BRCA	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2778
p.N85S	DO3686	BRCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2778
p.V87I	TCGA-BK-A6W3	UCEC	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7076
p.V87I	DO50076	UCEC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7076
p.R88S	TCGA-BR-8363	STAD	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7427
p.R88S	DO47837	STAD	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7427
p.P82Q	TCGA-CN-6010	HNSC	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1944
p.P82Q	DO14766	HNSC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1944
p.R80W	TCGA-D8-A1XT	BRCA	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.R80W	DO5912	BRCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.A99V	TCGA-DU-5855	LGG	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2222
p.A99V	DO22301	LGG	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2222
p.E89Q	DO225338	BRCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6744
p.R98W	DO222874	COCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.R80Q	DO233123	GACA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.A96S	DO233210	GACA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation blocking phosphorylation signal	0.75
p.S102P	DO10900	GBM	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.S102Y	DO228976	LICA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.H89N	DO229022	LICA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7423
p.T81N	DO229031	LICA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1667
p.A80S	DO230968	LUSC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.A80S	DO224621	LUSC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.L80Q	DO218841	SKCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.G79E	DO219774	UCEC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.P90L	SIDM02027	Colorectal Carcinoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7582
p.S87N	SIDM00845	Burkitt's Lymphoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7069
p.S87N	SIDM00461	Acute Myeloid Leukemia	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7069
p.H90R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7133
p.H90R	ACH-002256	Leukemia	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7133
p.H90R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7133
p.Q78K	SIDM00497	Colorectal Carcinoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.Q78K	ACH-000683	Colon/Colorectal Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.E83K	ACH-000847	Gastric Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2222
p.R228H	ACH-000952	Prostate Cancer	CCLE	PRTPPPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.P86L	ACH-001024	Skin Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.P86L	CHL-1	skin	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.P235L	KP-N-YS	autonomic ganglia	COSMIC	PRTPPPS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6471
p.P235L	BALL-1	haematopoietic and lymphoid tissue	COSMIC	PRTPPPS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6471
p.P102L	KP-N-YS	autonomic ganglia	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.P102L	BALL-1	haematopoietic and lymphoid tissue	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.P80L	BALL-1	haematopoietic and lymphoid tissue	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.P80L	KP-N-YS	autonomic ganglia	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389

Kaplan plot for MBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBP

UniProt ID: P02686

Entrez ID: 4155

Protein name: Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MBP in