DegronMD

Uniprot ID: P02686

Source protein: Myelin basic protein

Source gene: MBP

Class: DEG_APCC_DBOX_1

Location: 87:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.514

ASA_SCORE: 42.2

COIL: 0.4472

CONS_SCORE: 0.3366

DSS_SCORE: 0.6871

HELIX: 0.0837

FCONS_SCORE: 1.0113

RIG_SCORE: 0.6888

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R88H	TCGA-A5-A0G1	UCEC	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.8244
p.R88H	DO23206	LINC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.8244
p.R88H	DO42472	UCEC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.8244
p.R88H	SIDM00777	Colorectal Carcinoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	0.8244
p.R88H	ACH-000360	Colon/Colorectal Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	0.8244
p.R88H	NCI-H508	large_intestine	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.8244
p.N85S	TCGA-BH-A18G	BRCA	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.2778
p.N85S	DO3686	BRCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.2778
p.V87I	TCGA-BK-A6W3	UCEC	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.7076
p.V87I	DO50076	UCEC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7076
p.R88S	TCGA-BR-8363	STAD	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.7427
p.R88S	DO47837	STAD	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7427
p.P82Q	TCGA-CN-6010	HNSC	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.1944
p.P82Q	DO14766	HNSC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1944
p.R80W	TCGA-D8-A1XT	BRCA	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.R80W	DO5912	BRCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.A99V	TCGA-DU-5855	LGG	TCGA	SRPHLIRLF	DEG_APCC_DBOX_1	0.2222
p.A99V	DO22301	LGG	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.2222
p.E89Q	DO225338	BRCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.6744
p.R98W	DO222874	COCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.25
p.R80Q	DO233123	GACA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.A96S	DO233210	GACA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.75
p.S102P	DO10900	GBM	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.S102Y	DO228976	LICA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.H89N	DO229022	LICA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7423
p.T81N	DO229031	LICA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1667
p.A80S	DO230968	LUSC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.A80S	DO224621	LUSC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.L80Q	DO218841	SKCA	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.G79E	DO219774	UCEC	ICGC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1111
p.P90L	SIDM02027	Colorectal Carcinoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7582
p.S87N	SIDM00845	Burkitt's Lymphoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7069
p.S87N	SIDM00461	Acute Myeloid Leukemia	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7069
p.H90R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7133
p.H90R	ACH-002256	Leukemia	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	0.7133
p.H90R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.7133
p.Q78K	SIDM00497	Colorectal Carcinoma	GDSC	SRPHLIRLF	DEG_APCC_DBOX_1	0.0833
p.Q78K	ACH-000683	Colon/Colorectal Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	0.0833
p.E83K	ACH-000847	Gastric Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	0.2222
p.P86L	ACH-001024	Skin Cancer	CCLE	SRPHLIRLF	DEG_APCC_DBOX_1	0.3056
p.P86L	CHL-1	skin	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.3056
p.P102L	KP-N-YS	autonomic_ganglia	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.P102L	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.P80L	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389
p.P80L	KP-N-YS	autonomic_ganglia	COSMIC	SRPHLIRLF	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRPHLIRLF

Degron related mutations and impact score

Drug responses associated with MBP mutations

All proteins holding degron of SRPHLIRLF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02686	Myelin basic protein	DEG_APCC_DBOX_1	87:95	SRPHLIRLF	APC,CDC20,FZR1	0.514	More...