DegronMD

Uniprot ID: Q96LL9

Source protein: DnaJ homolog subfamily C member 30, mitochondrial

Source gene: DNAJC30

Class: DEG_SCF_FBW7_1

Location: 138:144

E3 ligase: FBXW7

DEGRON score: 0.7408

ASA_SCORE: 89.4429

COIL: 0.9609

CONS_SCORE: 0.4501

DSS_SCORE: 0.898

HELIX: 0.0163

FCONS_SCORE: 1.0167

RIG_SCORE: 0.4796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D149N	DO223004	ESCA	ICGC	PRTPPPT	DEG_SCF_FBW7_1	0.1944
p.S145Y	DO36556	READ	ICGC	PRTPPPT	DEG_SCF_FBW7_1	0.3056
p.G150A	SIDM00625	Other Sarcomas	GDSC	PRTPPPT	DEG_SCF_FBW7_1	0.1667
p.G150A	ACH-000449	Sarcoma	CCLE	PRTPPPT	DEG_SCF_FBW7_1	0.1667
p.G150A	MES-SA	soft_tissue	COSMIC	PRTPPPT	DEG_SCF_FBW7_1	0.1667
p.P133L	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PRTPPPT	DEG_SCF_FBW7_1	0.1944
p.S154F	SIDM01190	Bladder Carcinoma	GDSC	PRTPPPT	DEG_SCF_FBW7_1	0.0556
p.S154F	ACH-000720	Bladder Cancer	CCLE	PRTPPPT	DEG_SCF_FBW7_1	0.0556
p.S154F	TCCSUP	urinary_tract	COSMIC	PRTPPPT	DEG_SCF_FBW7_1	0.0556
p.R152G	SIDM00150	Colorectal Carcinoma	GDSC	PRTPPPT	DEG_SCF_FBW7_1	0.1111
p.R152G	ACH-000969	Colon/Colorectal Cancer	CCLE	PRTPPPT	DEG_SCF_FBW7_1	0.1111
p.R152G	KM12	large_intestine	COSMIC	PRTPPPT	DEG_SCF_FBW7_1	0.1111
p.R139P	SIDM01582	Gastric Carcinoma	GDSC	PRTPPPT	DEG_SCF_FBW7_1	0.6401
p.R139P	ACH-000507	Gastric Cancer	CCLE	PRTPPPT	DEG_SCF_FBW7_1	0.6401

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LL9	DnaJ homolog subfamily C member 30, mitochondrial	DEG_SCF_FBW7_1	138:144	PRTPPPT	FBXW7	0.7408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons