DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRTPQAE
Uniprot ID:
O95153
Source protein:
Peripheral-type benzodiazepine receptor-associated protein 1
Source gene:
TSPOAP1
Class:
DEG_SCF_FBW7_2
Location:
1840:1846
E3 ligase:
FBXW7
DEGRON score:
0.592
ASA_SCORE:
104.5714
COIL:
0.8237
CONS_SCORE:
0.2248
DSS_SCORE:
0.7798
HELIX:
0.1793
FCONS_SCORE:
0.6306
RIG_SCORE:
0.6449
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1850R
SIDM01210
Glioblastoma
GDSC
PRTPQAE
DEG_SCF_FBW7_2
0.2222
p.T1850R
KNS-81-FD
central_nervous_system
COSMIC
PRTPQAE
DEG_SCF_FBW7_2
0.2222
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Drug responses associated with TSPOAP1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PRTPQAE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95153
Peripheral-type benzodiazepine receptor-associated protein 1
DEG_SCF_FBW7_2
1840:1846
PRTPQAE
FBXW7
0.592
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