DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRTPQAE
Uniprot ID:
O95153
Source protein:
Peripheral-type benzodiazepine receptor-associated protein 1
Source gene:
TSPOAP1
Class:
DEG_SCF_FBW7_2
Location:
1840:1846
E3 ligase:
FBXW7
DEGRON score:
0.592
ASA_SCORE:
104.5714
COIL:
0.8237
CONS_SCORE:
0.2248
DSS_SCORE:
0.7798
HELIX:
0.1793
FCONS_SCORE:
0.6306
RIG_SCORE:
0.6449
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1850R
SIDM01210
Glioblastoma
GDSC
PRTPQAE
DEG_SCF_FBW7_2
0.2222
p.T1850R
KNS-81-FD
central_nervous_system
COSMIC
PRTPQAE
DEG_SCF_FBW7_2
0.2222
Drug responses associated with TSPOAP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRTPQAE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95153
Peripheral-type benzodiazepine receptor-associated protein 1
DEG_SCF_FBW7_2
1840:1846
PRTPQAE
FBXW7
0.592
More...