DegronMD

Uniprot ID: O00555

Source protein: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Source gene: CACNA1A

Class: DEG_SCF_FBW7_1

Location: 2452:2458

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 93.3857

COIL: 0.9316

CONS_SCORE: 0.1753

DSS_SCORE: 0.7093

HELIX: 0.0373

FCONS_SCORE: 1.0778

RIG_SCORE: 0.5672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2462L	SIDM00690	Head and Neck Carcinoma	GDSC	PRTPRAS	DEG_SCF_FBW7_1	0.2222
p.R2462L	SIDM00142	Endometrial Carcinoma	GDSC	PRTPRAS	DEG_SCF_FBW7_1	0.2222
p.A2447T	ACH-001375	Pancreatic Cancer	CCLE	PRTPRAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	DEG_SCF_FBW7_1	2452:2458	PRTPRAS	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons