DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_SCF_FBW7_1

Location: 1722:1728

E3 ligase: FBXW7

DEGRON score: 0.9841

ASA_SCORE: 91.7

COIL: 0.9581

CONS_SCORE: 0.4833

DSS_SCORE: 0.4197

HELIX: 0.0274

FCONS_SCORE: 1.1157

RIG_SCORE: 0.6987

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1738H	TCGA-4Z-AA87	BLCA	TCGA	PRTPSCS	DEG_SCF_FBW7_1	0.0556
p.D1738H	DO218990	BLCA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.0556
p.E1717K	TCGA-AC-A23H	BRCA	TCGA	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.E1717K	DO2401	BRCA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.C1712W	TCGA-AZ-5407	COAD	TCGA	PRTPSCS	DEG_SCF_FBW7_1	0.0556
p.C1712W	DO8432	COAD	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.0556
p.A1733V	TCGA-B5-A3FC	UCEC	TCGA	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.A1733V	DO41871	UCEC	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.A1733V	SIDM00238	Ovarian Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.A1729T	TCGA-G4-6302	COAD	TCGA	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	DO8778	COAD	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	SIDM00596	Endometrial Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	ACH-000941	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	ACH-000954	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1729T	HEC-1	endometrium	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	0.3056
p.A1733T	TCGA-JW-AAVH	CESC	TCGA	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.A1733T	DO51605	CESC	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.1944
p.P1713T	DO222769	COCA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.0833
p.S1728R	DO229025	LICA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.7427
p.D1731E	DO229006	LICA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1731V	SIDM00683	Prostate Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1731V	ACH-000977	lymph_node	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1731V	LNCaP-Clone-FGC	prostate	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1731G	SIDM00860	Head and Neck Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1731G	ACH-000846	Head and Neck Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1731G	FADU	upper_aerodigestive_tract	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	0.25
p.D1738G	SIDM00713	Mesothelioma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	0.0556
p.D1738G	ACH-000153	Lung Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	0.0556
p.D1738G	NCI-H2052	pleura	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTPSCS

Degron related mutations and impact score

Drug responses associated with ANKRD11 mutations

All proteins holding degron of PRTPSCS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SCF_FBW7_1	1722:1728	PRTPSCS	FBXW7	0.9841	More...