DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 11503:11510

E3 ligase: FBXW7

DEGRON score: 0.935

ASA_SCORE: 100.05

COIL: 0.8534

CONS_SCORE: 0

DSS_SCORE: 0.63

HELIX: 0.0161

FCONS_SCORE: 0

RIG_SCORE: 0.6888

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M11501I	TCGA-76-6656	GBM	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.M11501I	TCGA-CN-6010	HNSC	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.M11501I	DO13671	GBM	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.M11501I	DO14766	HNSC	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.V11520A	TCGA-D1-A177	UCEC	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.0556
p.V11520A	DO42528	UCEC	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.0556
p.P11503S	TCGA-D3-A8GM	SKCM	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.6752
p.P11503S	TCGA-GF-A6C9	SKCM	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.6752
p.P11503S	DO50288	SKCM	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.6752
p.P11503S	DO51254	SKCM	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.6752
p.P11495S	TCGA-EE-A185	SKCM	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495S	TCGA-IH-A3EA	SKCM	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495S	DO220898	MELA	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495S	DO222658	MELA	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495S	DO37667	SKCM	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495S	DO37599	SKCM	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.H11511Y	TCGA-EJ-5496	PRAD	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.3056
p.H11511Y	DO36266	PRAD	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.3056
p.V11502I	TCGA-FR-A726	SKCM	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.3056
p.V11502I	DO48665	SKCM	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.3056
p.F11509C	TCGA-IB-7651	PAAD	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.5996
p.F11509C	DO46657	PAAD	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.5996
p.S11510P	TCGA-L5-A8NV	ESCA	TCGA	PRTTPKFS	DEG_SCF_FBW7_1	0.6752
p.I11493T	DO224852	BRCA	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.0556
p.I11493T	DO52550	BRCA	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.0556
p.N11499T	DO233206	GACA	ICGC	PRTTPKFS	DEG_SCF_FBW7_1	0.2222
p.A11496E	SIDM00781	Colorectal Carcinoma	GDSC	PRTTPKFS	DEG_SCF_FBW7_1	0.1389
p.A11496E	SIDM00780	Colorectal Carcinoma	GDSC	PRTTPKFS	DEG_SCF_FBW7_1	0.1389
p.A11496E	ACH-000967	Colon/Colorectal Cancer	CCLE	PRTTPKFS	DEG_SCF_FBW7_1	0.1389
p.A11496E	ACH-001199	Colon/Colorectal Cancer	CCLE	PRTTPKFS	DEG_SCF_FBW7_1	0.1389
p.A11496E	SNU-C2B	large_intestine	COSMIC	PRTTPKFS	DEG_SCF_FBW7_1	0.1389
p.V11502F	SIDM01110	Hepatocellular Carcinoma	GDSC	PRTTPKFS	DEG_SCF_FBW7_1	0.3056
p.V11502F	SK-HEP-1	liver	COSMIC	PRTTPKFS	DEG_SCF_FBW7_1	0.3056
p.S11512G	SIDM00537	Colorectal Carcinoma	GDSC	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.S11512G	ACH-000982	Colon/Colorectal Cancer	CCLE	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.S11512G	ACH-001345	Colon/Colorectal Cancer	CCLE	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.S11512G	GP5d	large_intestine	COSMIC	PRTTPKFS	DEG_SCF_FBW7_1	0.2778
p.P11495H	SIDM00720	Mesothelioma	GDSC	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495L	ACH-002396	Bone Cancer	CCLE	PRTTPKFS	DEG_SCF_FBW7_1	0.1111
p.P11495L	Sarc9371	bone	COSMIC	PRTTPKFS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTTPKFS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PRTTPKFS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	11503:11510	PRTTPKFS	FBXW7	0.935	More...