DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 11362:11369

E3 ligase: FBXW7

DEGRON score: 0.8754

ASA_SCORE: 100.3

COIL: 0.9149

CONS_SCORE: 0

DSS_SCORE: 0.6668

HELIX: 0.0135

FCONS_SCORE: 0

RIG_SCORE: 0.638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11354S	TCGA-BF-A1PV	SKCM	TCGA	PRTTPNYS	DEG_SCF_FBW7_1	0.1111
p.P11354S	DO220872	MELA	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.1111
p.P11354S	DO47309	SKCM	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.1111
p.P11362L	TCGA-CX-7086	HNSC	TCGA	PRTTPNYS	DEG_SCF_FBW7_1	0.6471
p.P11362L	DO15046	HNSC	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.6471
p.D11374N	TCGA-Z2-A8RT	SKCM	TCGA	PRTTPNYS	DEG_SCF_FBW7_1	0.1944
p.D11374N	DO51301	SKCM	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.1944
p.T11376K	DO233704	GACA	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.1389
p.H11370N	DO229028	LICA	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.3056
p.E11372K	DO222418	MELA	ICGC	PRTTPNYS	DEG_SCF_FBW7_1	0.25
p.N11367S	SIDM00303	Ovarian Carcinoma	GDSC	PRTTPNYS	DEG_SCF_FBW7_1	0.5958
p.N11367S	ACH-000584	Ovarian Cancer	CCLE	PRTTPNYS	DEG_SCF_FBW7_1	0.5958
p.N11367S	JHOS-4	ovary	COSMIC	PRTTPNYS	DEG_SCF_FBW7_1	0.5958
p.P11366A	ACH-002069	Bone Cancer	CCLE	PRTTPNYS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	11362:11369	PRTTPNYS	FBXW7	0.8754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons