DegronMD

Uniprot ID: P51172

Source protein: Amiloride-sensitive sodium channel subunit delta

Source gene: SCNN1D

Class: DEG_APCC_DBOX_1

Location: 774:782

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9977

ASA_SCORE: 63.4

COIL: 0.8178

CONS_SCORE: 0

DSS_SCORE: 0.5633

HELIX: 0.0371

FCONS_SCORE: 0

RIG_SCORE: 0.7093

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R775W	SIDM00199	Chondrosarcoma	GDSC	PRVMLPGVL	DEG_APCC_DBOX_1	0.8634
p.M777I	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PRVMLPGVL	DEG_APCC_DBOX_1	0.6507
p.G784R	TCGA-W3-AA1Q	SKCM	TCGA	PRVMLPGVL	DEG_APCC_DBOX_1	0.2778
p.G784E	SIDM00481	Ovarian Carcinoma	GDSC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2778
p.G784E	OAW-28	ovary	COSMIC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2778
p.V785A	DO229224	THCA	ICGC	PRVMLPGVL	DEG_APCC_DBOX_1	0.25
p.G770R	DO228483	BRCA	ICGC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2222
p.G770R	DO230334	COCA	ICGC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2222
p.G770R	DO229003	COCA	ICGC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2222
p.G770R	DO229353	LAML	ICGC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2222
p.S786L	SIDM00995	Other Solid Cancers	GDSC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2222
p.S786L	A431	skin	COSMIC	PRVMLPGVL	DEG_APCC_DBOX_1	0.2222
p.E788K	DO225051	BRCA	ICGC	PRVMLPGVL	DEG_APCC_DBOX_1	0.1667
p.E788K	SIDM02069	Colorectal Carcinoma	GDSC	PRVMLPGVL	DEG_APCC_DBOX_1	0.1667

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51172	Amiloride-sensitive sodium channel subunit delta	DEG_APCC_DBOX_1	774:782	PRVMLPGVL	APC,CDC20,FZR1	0.9977	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons