DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PRVMLPGVL
Uniprot ID:
P51172
Source protein:
Amiloride-sensitive sodium channel subunit delta
Source gene:
SCNN1D
Class:
DEG_APCC_DBOX_1
Location:
774:782
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9977
ASA_SCORE:
63.4
COIL:
0.8178
CONS_SCORE:
0
DSS_SCORE:
0.5633
HELIX:
0.0371
FCONS_SCORE:
0
RIG_SCORE:
0.7093
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G784R
TCGA-W3-AA1Q
SKCM
TCGA
PRVMLPGVL
DEG_APCC_DBOX_1
0.2778
p.E788K
DO225051
BRCA
ICGC
PRVMLPGVL
DEG_APCC_DBOX_1
0.1667
p.E788K
SIDM02069
Colorectal Carcinoma
GDSC
PRVMLPGVL
DEG_APCC_DBOX_1
0.1667
p.G770R
DO228483
BRCA
ICGC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2222
p.G770R
DO230334
COCA
ICGC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2222
p.G770R
DO229003
COCA
ICGC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2222
p.G770R
DO229353
LAML
ICGC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2222
p.V785A
DO229224
THCA
ICGC
PRVMLPGVL
DEG_APCC_DBOX_1
0.25
p.G784E
SIDM00481
Ovarian Carcinoma
GDSC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2778
p.G784E
OAW-28
ovary
COSMIC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2778
p.S786L
SIDM00995
Other Solid Cancers
GDSC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2222
p.S786L
A431
skin
COSMIC
PRVMLPGVL
DEG_APCC_DBOX_1
0.2222
p.R775W
SIDM00199
Chondrosarcoma
GDSC
PRVMLPGVL
DEG_APCC_DBOX_1
0.8634
p.M777I
SIDM01689
B-Lymphoblastic Leukemia
GDSC
PRVMLPGVL
DEG_APCC_DBOX_1
0.6507
Drug responses associated with SCNN1D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRVMLPGVL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P51172
Amiloride-sensitive sodium channel subunit delta
DEG_APCC_DBOX_1
774:782
PRVMLPGVL
APC,CDC20,FZR1
0.9977
More...