DegronMD

Uniprot ID: Q6UWD8

Source protein: Transmembrane protein C16orf54

Source gene: C16orf54

Class: DEG_APCC_DBOX_1

Location: 203:211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8941

ASA_SCORE: 53.4222

COIL: 0.3104

CONS_SCORE: 0.998

DSS_SCORE: 0.4284

HELIX: 0.5629

FCONS_SCORE: 1.1897

RIG_SCORE: 0.8166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L201F	TCGA-BH-A0HF	BRCA	TCGA	PRVTLEQIS	DEG_APCC_DBOX_1	0.2778
p.L201F	DO1749	BRCA	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.2778
p.W214R	TCGA-D3-A8GM	SKCM	TCGA	PRVTLEQIS	DEG_APCC_DBOX_1	0.25
p.W214R	DO50288	SKCM	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.25
p.R204W	TCGA-EJ-5505	PRAD	TCGA	PRVTLEQIS	DEG_APCC_DBOX_1	0.8634
p.R204W	DO36337	PRAD	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.8634
p.R219Q	TCGA-ER-A42L	SKCM	TCGA	PRVTLEQIS	DEG_APCC_DBOX_1	0.1111
p.R219Q	DO223910	SKCM	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.1111
p.E208K	TCGA-FW-A3R5	SKCM	TCGA	PRVTLEQIS	DEG_APCC_DBOX_1	0.591
p.E208K	DO228471	BRCA	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.591
p.E208K	DO37406	SKCM	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.591
p.Q202L	TCGA-UB-A7MB	LIHC	TCGA	PRVTLEQIS	DEG_APCC_DBOX_1	0.3056
p.Q202L	DO52318	LIHC	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.3056
p.R204Q	DO23500	LINC	ICGC	PRVTLEQIS	DEG_APCC_DBOX_1	0.7329
p.V205I	SIDM01943	Colorectal Carcinoma	GDSC	PRVTLEQIS	DEG_APCC_DBOX_1	0.5965
p.P197H	SIDM00781	Colorectal Carcinoma	GDSC	PRVTLEQIS	DEG_APCC_DBOX_1	0.1667
p.P197H	ACH-001199	Colon/Colorectal Cancer	CCLE	PRVTLEQIS	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWD8	Transmembrane protein C16orf54	DEG_APCC_DBOX_1	203:211	PRVTLEQIS	APC,CDC20,FZR1	0.8941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons