DegronMD

Uniprot ID: P35520

Source protein: Cystathionine beta-synthase

Source gene: CBS

Class: DEG_SCF_FBW7_2

Location: 2:9

E3 ligase: FBXW7

DEGRON score: 0.962

ASA_SCORE: 99.45

COIL: 0.868

CONS_SCORE: 0.2673

DSS_SCORE: 0.9237

HELIX: 0.094

FCONS_SCORE: 0.9953

RIG_SCORE: 0.6132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4G	TCGA-A5-A0G1	UCEC	TCGA	PSETPQAE	DEG_SCF_FBW7_2	0.6087
p.E4G	DO42472	UCEC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.6087
p.R18C	TCGA-D1-A17D	UCEC	TCGA	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18C	DO52365	LUSC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18C	DO41746	UCEC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18C	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18H	TCGA-SJ-A6ZI	UCEC	TCGA	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18H	DO230318	COCA	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18H	DO219784	UCEC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18H	ACH-001369	Ovarian Cancer	CCLE	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.E16D	DO6470	CLLE	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.1389
p.L17I	DO220312	SARC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	0.1111
p.R18S	ACH-000916	Lung Cancer	CCLE	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.R18S	NCI-H1573	lung	COSMIC	PSETPQAE	DEG_SCF_FBW7_2	0.0833
p.P6S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSETPQAE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35520	Cystathionine beta-synthase	DEG_SCF_FBW7_2	2:9	PSETPQAE	FBXW7	0.962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons