DegronMD - P35520(CBS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E4G	TCGA-A5-A0G1	UCEC	TCGA	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation altering degron motif	0.6087
p.E4G	DO42472	UCEC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation altering degron motif	0.6087
p.R18C	TCGA-D1-A17D	UCEC	TCGA	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18C	TCGA-D1-A17D	UCEC	TCGA	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18C	DO52365	LUSC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18C	DO52365	LUSC	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18C	DO41746	UCEC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18C	DO41746	UCEC	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18C	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18C	CTB-1	haematopoietic and lymphoid tissue	COSMIC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18H	TCGA-SJ-A6ZI	UCEC	TCGA	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18H	TCGA-SJ-A6ZI	UCEC	TCGA	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18H	DO230318	COCA	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18H	DO230318	COCA	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18H	DO219784	UCEC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18H	DO219784	UCEC	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18H	ACH-001369	Ovarian Cancer	CCLE	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18H	ACH-001369	Ovarian Cancer	CCLE	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.E16D	DO6470	CLLE	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.1389
p.E16D	DO6470	CLLE	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.25
p.G12S	DO7828	COAD	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation altering degron motif	0.6993
p.L17I	DO220312	SARC	ICGC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.1111
p.L17I	DO220312	SARC	ICGC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.2222
p.R18S	ACH-000916	Lung Cancer	CCLE	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18S	ACH-000916	Lung Cancer	CCLE	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.R18S	NCI-H1573	lung	COSMIC	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation rewiring degron network	0.0833
p.R18S	NCI-H1573	lung	COSMIC	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation rewiring degron network	0.1944
p.P6S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSETPQAE	DEG_SCF_FBW7_2	2:9	Mutation altering degron motif	0.6752
p.P6S	ACH-000996	Endometrial/Uterine Cancer	CCLE	TPQAEVGPT	DEG_SIAH_1	5:13	Mutation altering degron motif	0.6752

Kaplan plot for CBS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBS

UniProt ID: P35520

Entrez ID: 102724560

Protein name: Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBS in