DegronMD

Uniprot ID: P35520

Source protein: Cystathionine beta-synthase

Source gene: CBS

Class: DEG_SIAH_1

Location: 5:13

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9275

ASA_SCORE: 87.5667

COIL: 0.8682

CONS_SCORE: 0.2633

DSS_SCORE: 0.8503

HELIX: 0.0842

FCONS_SCORE: 0.9884

RIG_SCORE: 0.5846

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R18C	TCGA-D1-A17D	UCEC	TCGA	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18C	DO52365	LUSC	ICGC	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18C	DO41746	UCEC	ICGC	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18C	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18H	TCGA-SJ-A6ZI	UCEC	TCGA	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18H	DO230318	COCA	ICGC	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18H	DO219784	UCEC	ICGC	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18H	ACH-001369	Ovarian Cancer	CCLE	TPQAEVGPT	DEG_SIAH_1	0.1944
p.E16D	DO6470	CLLE	ICGC	TPQAEVGPT	DEG_SIAH_1	0.25
p.G12S	DO7828	COAD	ICGC	TPQAEVGPT	DEG_SIAH_1	0.6993
p.L17I	DO220312	SARC	ICGC	TPQAEVGPT	DEG_SIAH_1	0.2222
p.R18S	ACH-000916	Lung Cancer	CCLE	TPQAEVGPT	DEG_SIAH_1	0.1944
p.R18S	NCI-H1573	lung	COSMIC	TPQAEVGPT	DEG_SIAH_1	0.1944
p.P6S	ACH-000996	Endometrial/Uterine Cancer	CCLE	TPQAEVGPT	DEG_SIAH_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35520	Cystathionine beta-synthase	DEG_SIAH_1	5:13	TPQAEVGPT	SIAH1,SIAH2,SIAH3	0.9275	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons