DegronMD

Uniprot ID: Q9BVT8

Source protein: Transmembrane and ubiquitin-like domain-containing protein 1

Source gene: TMUB1

Class: DEG_SCF_FBW7_1

Location: 43:50

E3 ligase: FBXW7

DEGRON score: 0.9182

ASA_SCORE: 81.475

COIL: 0.9553

CONS_SCORE: 0.447

DSS_SCORE: 0.791

HELIX: 0.0198

FCONS_SCORE: 0.9622

RIG_SCORE: 0.5426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D38N	TCGA-FI-A2D5	UCEC	TCGA	PSGTPTPS	DEG_SCF_FBW7_1	0.1944
p.D38N	DO41331	UCEC	ICGC	PSGTPTPS	DEG_SCF_FBW7_1	0.1944
p.P52L	DO222494	MELA	ICGC	PSGTPTPS	DEG_SCF_FBW7_1	0.2778
p.A57V	SIDM00615	Hepatocellular Carcinoma	GDSC	PSGTPTPS	DEG_SCF_FBW7_1	0.1389
p.A57V	ACH-000217	Liver Cancer	CCLE	PSGTPTPS	DEG_SCF_FBW7_1	0.1389
p.A57V	JHH-6	liver	COSMIC	PSGTPTPS	DEG_SCF_FBW7_1	0.1389
p.A54T	SIDM00220	Ovarian Carcinoma	GDSC	PSGTPTPS	DEG_SCF_FBW7_1	0.2222
p.A54T	ACH-000962	Ovarian Cancer	CCLE	PSGTPTPS	DEG_SCF_FBW7_1	0.2222
p.A54T	ACH-001145	Ovarian Cancer	CCLE	PSGTPTPS	DEG_SCF_FBW7_1	0.2222
p.A54T	OC-314	ovary	COSMIC	PSGTPTPS	DEG_SCF_FBW7_1	0.2222
p.T48S	SIDM01781	Gastric Carcinoma	GDSC	PSGTPTPS	DEG_SCF_FBW7_1	0.6005
p.T48S	ACH-000325	Gastric Cancer	CCLE	PSGTPTPS	DEG_SCF_FBW7_1	0.6005
p.T48A	SIDM00784	Glioma	GDSC	PSGTPTPS	DEG_SCF_FBW7_1	0.6028
p.T48A	ACH-000126	Brain Cancer	CCLE	PSGTPTPS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVT8	Transmembrane and ubiquitin-like domain-containing protein 1	DEG_SCF_FBW7_1	43:50	PSGTPTPS	FBXW7	0.9182	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons