DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SCF_FBW7_2

Location: 385:392

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 80.4125

COIL: 0.9085

CONS_SCORE: 0.4051

DSS_SCORE: 0.4926

HELIX: 0.0284

FCONS_SCORE: 1.2693

RIG_SCORE: 0.6939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L387M	TCGA-18-3411	LUSC	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.5999
p.L387M	DO26758	LUSC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.5999
p.L387V	TCGA-85-A50Z	LUSC	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.5654
p.L387V	DO45462	LUSC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.5654
p.S386Y	TCGA-AP-A059	UCEC	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.712
p.S386Y	DO41361	UCEC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.712
p.R379Q	TCGA-AX-A05Z	UCEC	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.1667
p.R379Q	TCGA-EO-A22X	UCEC	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.1667
p.R379Q	DO222762	COCA	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.1667
p.R379Q	DO40884	UCEC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.1667
p.R379Q	DO43907	UCEC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.1667
p.S380I	TCGA-D1-A103	UCEC	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.6389
p.S380I	DO42312	UCEC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.6389
p.R394M	TCGA-EE-A2GM	SKCM	TCGA	PSLTPSGE	DEG_SCF_FBW7_2	0.2778
p.R394M	DO37555	SKCM	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.2778
p.N402K	DO229016	COCA	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.0556
p.N402K	DO230659	LAML	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.0556
p.N402K	DO228947	LICA	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.0556
p.N402K	DO52365	LUSC	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.0556
p.P385Q	DO228971	LICA	ICGC	PSLTPSGE	DEG_SCF_FBW7_2	0.7035
p.I375V	SIDM00173	Head and Neck Carcinoma	GDSC	PSLTPSGE	DEG_SCF_FBW7_2	0.0556
p.I375V	ACH-000618	Head and Neck Cancer	CCLE	PSLTPSGE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49790	Nuclear pore complex protein Nup153	DEG_SCF_FBW7_2	385:392	PSLTPSGE	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons