DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_2

Location: 1819:1826

E3 ligase: FBXW7

DEGRON score: 0.8966

ASA_SCORE: 97.55

COIL: 0.9229

CONS_SCORE: 0

DSS_SCORE: 0.5315

HELIX: 0.0204

FCONS_SCORE: 0

RIG_SCORE: 0.655

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1826V	TCGA-55-7994	LUAD	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.7693
p.E1826V	DO45311	LUAD	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.7693
p.L1835R	TCGA-D1-A16X	UCEC	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.0833
p.L1835R	DO41799	UCEC	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.0833
p.M1825L	TCGA-EY-A1G8	UCEC	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.5999
p.M1825L	DO43578	UCEC	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.5999
p.T1822S	TCGA-FG-6690	LGG	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.7116
p.T1822S	DO22141	LGG	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.7116
p.E1809K	TCGA-FR-A7U9	SKCM	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.0556
p.E1809K	TCGA-WE-A8K4	SKCM	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.0556
p.E1809K	DO48546	SKCM	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.0556
p.E1809K	DO51281	SKCM	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.0556
p.P1819S	TCGA-W3-AA1V	SKCM	TCGA	PSPTPSME	DEG_SCF_FBW7_2	0.6752
p.P1819S	DO51276	SKCM	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.6752
p.L1833F	DO229010	COCA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.L1833F	DO229016	COCA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.L1833F	DO229003	COCA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.L1833F	DO229005	COCA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.L1833F	DO234285	ESAD	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.L1833F	DO229047	LICA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.L1833F	DO52365	LUSC	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1389
p.P1819Q	DO228948	LICA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.7035
p.T1834I	DO229048	LICA	ICGC	PSPTPSME	DEG_SCF_FBW7_2	0.1111
p.S1820T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PSPTPSME	DEG_SCF_FBW7_2	0.6005
p.S1820T	ACH-002176	Lung Cancer	CCLE	PSPTPSME	DEG_SCF_FBW7_2	0.6005
p.S1820T	NCI-H748	lung	COSMIC	PSPTPSME	DEG_SCF_FBW7_2	0.6005
p.D1817N	SIDM01060	Melanoma	GDSC	PSPTPSME	DEG_SCF_FBW7_2	0.2778
p.D1817N	ACH-000882	Skin Cancer	CCLE	PSPTPSME	DEG_SCF_FBW7_2	0.2778
p.D1817N	IGR-1	skin	COSMIC	PSPTPSME	DEG_SCF_FBW7_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSPTPSME

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PSPTPSME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_2	1819:1826	PSPTPSME	FBXW7	0.8966	More...