DegronMD

Uniprot ID: Q6B0I6

Source protein: Lysine-specific demethylase 4D

Source gene: KDM4D

Class: DEG_SCF_FBW7_1

Location: 429:436

E3 ligase: FBXW7

DEGRON score: 0.9686

ASA_SCORE: 91.725

COIL: 0.9624

CONS_SCORE: 0.4027

DSS_SCORE: 0.791

HELIX: 0.0146

FCONS_SCORE: 1.0699

RIG_SCORE: 0.4689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S430T	TCGA-23-1029	OV	TCGA	PSSTPSST	DEG_SCF_FBW7_1	0.6005
p.S430T	DO28571	OV	ICGC	PSSTPSST	DEG_SCF_FBW7_1	0.6005
p.T432S	TCGA-A1-A0SO	BRCA	TCGA	PSSTPSST	DEG_SCF_FBW7_1	0.7116
p.T432S	DO2020	BRCA	ICGC	PSSTPSST	DEG_SCF_FBW7_1	0.7116
p.G438C	TCGA-D3-A2JP	SKCM	TCGA	PSSTPSST	DEG_SCF_FBW7_1	0.2778
p.G438C	DO47407	SKCM	ICGC	PSSTPSST	DEG_SCF_FBW7_1	0.2778
p.S435F	TCGA-JW-A5VL	CESC	TCGA	PSSTPSST	DEG_SCF_FBW7_1	0.6871
p.S435F	DO49976	CESC	ICGC	PSSTPSST	DEG_SCF_FBW7_1	0.6871
p.I444S	TCGA-VQ-A8P5	STAD	TCGA	PSSTPSST	DEG_SCF_FBW7_1	0.1111
p.I444S	DO51763	STAD	ICGC	PSSTPSST	DEG_SCF_FBW7_1	0.1111
p.V423A	DO8858	COAD	ICGC	PSSTPSST	DEG_SCF_FBW7_1	0.1667
p.R419L	SIDM00521	Small Cell Lung Carcinoma	GDSC	PSSTPSST	DEG_SCF_FBW7_1	0.0556
p.R419L	ACH-000743	Lung Cancer	CCLE	PSSTPSST	DEG_SCF_FBW7_1	0.0556
p.R419L	COR-L95	lung	COSMIC	PSSTPSST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6B0I6	Lysine-specific demethylase 4D	DEG_SCF_FBW7_1	429:436	PSSTPSST	FBXW7	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons