DegronMD

Uniprot ID: Q9P203

Source protein: BTB/POZ domain-containing protein 7

Source gene: BTBD7

Class: DEG_SCF_FBW7_1

Location: 955:961

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 77

COIL: 0.9213

CONS_SCORE: 0.3744

DSS_SCORE: 0.6169

HELIX: 0.043

FCONS_SCORE: 1.0349

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T964P	TCGA-38-4632	LUAD	TCGA	PSTPALS	DEG_SCF_FBW7_1	0.6944
p.T964P	DO23858	LUAD	ICGC	PSTPALS	DEG_SCF_FBW7_1	0.6944
p.P967S	TCGA-D3-A3C8	SKCM	TCGA	PSTPALS	DEG_SCF_FBW7_1	0.1667
p.P967S	DO47636	SKCM	ICGC	PSTPALS	DEG_SCF_FBW7_1	0.1667
p.Q969H	TCGA-MP-A4TD	LUAD	TCGA	PSTPALS	DEG_SCF_FBW7_1	0.1111
p.Q969H	DO45363	LUAD	ICGC	PSTPALS	DEG_SCF_FBW7_1	0.1111
p.F945L	DO233652	GACA	ICGC	PSTPALS	DEG_SCF_FBW7_1	0.0556
p.P967L	ACH-001563	Skin Cancer	CCLE	PSTPALS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P203	BTB/POZ domain-containing protein 7	DEG_SCF_FBW7_1	955:961	PSTPALS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons