DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4229:4235

E3 ligase: FBXW7

DEGRON score: 0.5371

ASA_SCORE: 79.3429

COIL: 0.8724

CONS_SCORE: 0.3452

DSS_SCORE: 0.1878

HELIX: 0.018

FCONS_SCORE: 1.0301

RIG_SCORE: 0.7162

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4219S	TCGA-CN-4727	HNSC	TCGA	PSTPATS	DEG_SCF_FBW7_1	0.0556
p.A4233T	TCGA-EO-A3B0	UCEC	TCGA	PSTPATS	DEG_SCF_FBW7_1	0.6028
p.M4239T	TCGA-F4-6856	COAD	TCGA	PSTPATS	DEG_SCF_FBW7_1	0.2222
p.M4239T	22RV1	prostate	COSMIC	PSTPATS	DEG_SCF_FBW7_1	0.2222
p.M4239T	SNU-175	large_intestine	COSMIC	PSTPATS	DEG_SCF_FBW7_1	0.2222
p.G4226S	TCGA-GS-A9TZ	DLBC	TCGA	PSTPATS	DEG_SCF_FBW7_1	0.25
p.P4232L	TCGA-QC-A6FX	SARC	TCGA	PSTPATS	DEG_SCF_FBW7_1	0.7582
p.G4229S	DO219918	DLBC	ICGC	PSTPATS	DEG_SCF_FBW7_1	0.6993
p.G4229S	DO229227	THCA	ICGC	PSTPATS	DEG_SCF_FBW7_1	0.6993
p.R4222S	DO14258	HNSC	ICGC	PSTPATS	DEG_SCF_FBW7_1	0.1389
p.P4232H	DO228835	LICA	ICGC	PSTPATS	DEG_SCF_FBW7_1	0.7694
p.P4235L	DO220237	SARC	ICGC	PSTPATS	DEG_SCF_FBW7_1	0.7582
p.E4220K	DO51276	SKCM	ICGC	PSTPATS	DEG_SCF_FBW7_1	0.0833
p.R4219C	SIDM00602	Gastric Carcinoma	GDSC	PSTPATS	DEG_SCF_FBW7_1	0.0556
p.T4237K	SIDM00652	Small Cell Lung Carcinoma	GDSC	PSTPATS	DEG_SCF_FBW7_1	0.2778
p.T4237K	ACH-000780	Lung Cancer	CCLE	PSTPATS	DEG_SCF_FBW7_1	0.2778
p.T4237K	NCI-H1105	lung	COSMIC	PSTPATS	DEG_SCF_FBW7_1	0.2778
p.T4234A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PSTPATS	DEG_SCF_FBW7_1	0.6028
p.T4234A	ACH-002238	Leukemia	CCLE	PSTPATS	DEG_SCF_FBW7_1	0.6028
p.T4234A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPATS	DEG_SCF_FBW7_1	0.6028
p.T4237M	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PSTPATS	DEG_SCF_FBW7_1	0.2778
p.T4237M	ACH-001738	Leukemia	CCLE	PSTPATS	DEG_SCF_FBW7_1	0.2778
p.T4237M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPATS	DEG_SCF_FBW7_1	0.2778
p.S4235R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSTPATS	DEG_SCF_FBW7_1	0.7427
p.S4235R	ACH-001127	Leukemia	CCLE	PSTPATS	DEG_SCF_FBW7_1	0.7427
p.S4235R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPATS	DEG_SCF_FBW7_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPATS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSTPATS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4229:4235	PSTPATS	FBXW7	0.5371	More...