DegronMD

Uniprot ID: Q9UHI7

Source protein: Solute carrier family 23 member 1

Source gene: SLC23A1

Class: DEG_SCF_FBW7_1

Location: 19:25

E3 ligase: FBXW7

DEGRON score: 0.8087

ASA_SCORE: 95.6429

COIL: 0.9726

CONS_SCORE: 0.225

DSS_SCORE: 0.6097

HELIX: 0.0151

FCONS_SCORE: 0.8595

RIG_SCORE: 0.6542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19H	TCGA-BR-8360	STAD	TCGA	PSTPLPT	DEG_SCF_FBW7_1	0.7694
p.P19H	DO47745	STAD	ICGC	PSTPLPT	DEG_SCF_FBW7_1	0.7694
p.P22Q	TCGA-EE-A29V	SKCM	TCGA	PSTPLPT	DEG_SCF_FBW7_1	0.7035
p.P22Q	DO38006	SKCM	ICGC	PSTPLPT	DEG_SCF_FBW7_1	0.7035
p.F29L	TCGA-G4-6309	COAD	TCGA	PSTPLPT	DEG_SCF_FBW7_1	0.2222
p.F29L	DO7810	COAD	ICGC	PSTPLPT	DEG_SCF_FBW7_1	0.2222
p.P27S	TCGA-MH-A55Z	KIRP	TCGA	PSTPLPT	DEG_SCF_FBW7_1	0.2778
p.P27S	DO48482	KIRP	ICGC	PSTPLPT	DEG_SCF_FBW7_1	0.2778
p.M31I	SIDM00282	Colorectal Carcinoma	GDSC	PSTPLPT	DEG_SCF_FBW7_1	0.1667
p.M31I	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPLPT	DEG_SCF_FBW7_1	0.1667
p.M31I	CW-2	large_intestine	COSMIC	PSTPLPT	DEG_SCF_FBW7_1	0.1667
p.K28T	SIDM01611	Endometrial Carcinoma	GDSC	PSTPLPT	DEG_SCF_FBW7_1	0.3611
p.K28T	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSTPLPT	DEG_SCF_FBW7_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHI7	Solute carrier family 23 member 1	DEG_SCF_FBW7_1	19:25	PSTPLPT	FBXW7	0.8087	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons