DegronMD

Uniprot ID: Q5U5Q3

Source protein: RNA-binding E3 ubiquitin-protein ligase MEX3C

Source gene: MEX3C

Class: DEG_SCF_FBW7_1

Location: 539:545

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 77.2

COIL: 0.9386

CONS_SCORE: 0.4738

DSS_SCORE: 0.7863

HELIX: 0.0207

FCONS_SCORE: 1.0869

RIG_SCORE: 0.5694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P546L	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPRLS	DEG_SCF_FBW7_1	0.3056
p.R534C	SIDM00518	Mesothelioma	GDSC	PSTPRLS	DEG_SCF_FBW7_1	0.1944
p.R534C	H290	pleura	COSMIC	PSTPRLS	DEG_SCF_FBW7_1	0.1944
p.I552V	SIDM00282	Colorectal Carcinoma	GDSC	PSTPRLS	DEG_SCF_FBW7_1	0.1389
p.I552V	CW-2	large_intestine	COSMIC	PSTPRLS	DEG_SCF_FBW7_1	0.1389
p.R543H	SIDM01460	Glioma	GDSC	PSTPRLS	DEG_SCF_FBW7_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U5Q3	RNA-binding E3 ubiquitin-protein ligase MEX3C	DEG_SCF_FBW7_1	539:545	PSTPRLS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons