DegronMD

Uniprot ID: Q8NEB9

Source protein: Phosphatidylinositol 3-kinase catalytic subunit type 3

Source gene: PIK3C3

Class: DEG_SCF_FBW7_1

Location: 156:163

E3 ligase: FBXW7

DEGRON score: 0.9509

ASA_SCORE: 77.85

COIL: 0.912

CONS_SCORE: 0.4231

DSS_SCORE: 0.7154

HELIX: 0.031

FCONS_SCORE: 1.0737

RIG_SCORE: 0.6118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S164I	TCGA-85-6798	LUSC	TCGA	PTKTPGRT	DEG_SCF_FBW7_1	0.75
p.S164I	DO27295	LUSC	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.75
p.D170N	TCGA-AJ-A5DW	UCEC	TCGA	PTKTPGRT	DEG_SCF_FBW7_1	0.1389
p.R147Q	DO13863	GBM	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.0833
p.M152I	DO229026	LICA	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.2222
p.C163F	DO229045	LICA	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.7108
p.N150Y	DO49875	LUAD	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.1667
p.V161F	DO24800	LUAD	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.7068
p.L154M	DO50278	SKCM	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.2778
p.I170V	DO51783	STAD	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.1389
p.L154P	DO229213	THCA	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.2778
p.E157K	DO52402	UCEC	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	0.7022
p.T166S	SIDM00596	Endometrial Carcinoma	GDSC	PTKTPGRT	DEG_SCF_FBW7_1	0.25
p.T166S	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	0.25
p.T166S	ACH-000954	Endometrial/Uterine Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	0.25
p.T166S	ACH-001517	Endometrial/Uterine Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	0.25
p.T166S	HEC-1	endometrium	COSMIC	PTKTPGRT	DEG_SCF_FBW7_1	0.25
p.R162K	SIDM00170	Head and Neck Carcinoma	GDSC	PTKTPGRT	DEG_SCF_FBW7_1	0.6126
p.R162K	ACH-000682	Head and Neck Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	0.6126
p.M155I	EMC-BAC-1	lung	COSMIC	PTKTPGRT	DEG_SCF_FBW7_1	0.3056
p.Y173D	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PTKTPGRT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	DEG_SCF_FBW7_1	156:163	PTKTPGRT	FBXW7	0.9509	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons