DegronMD - Q8NEB9(PIK3C3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S164I	TCGA-85-6798	LUSC	TCGA	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation blocking phosphorylation signal	0.75
p.S164I	DO27295	LUSC	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation blocking phosphorylation signal	0.75
p.A290T	TCGA-A5-A0G2	UCEC	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.2778
p.A290T	DO41235	UCEC	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.2778
p.D170N	TCGA-AJ-A5DW	UCEC	TCGA	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1389
p.S282Y	TCGA-BF-A1PZ	SKCM	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation blocking phosphorylation signal	0.5
p.S282Y	DO50279	SKCM	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation blocking phosphorylation signal	0.5
p.P256T	TCGA-C5-A8YQ	CESC	TCGA	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.7031
p.E251K	TCGA-CD-A489	STAD	TCGA	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.7022
p.P258L	TCGA-DA-A95Y	SKCM	TCGA	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.6471
p.P245L	TCGA-EE-A20C	SKCM	TCGA	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.25
p.L296F	TCGA-EO-A22R	UCEC	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation altering degron motif	0.6981
p.L296F	DO42713	UCEC	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation altering degron motif	0.6981
p.E263D	TCGA-EY-A1GI	UCEC	TCGA	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1944
p.E263D	DO41211	UCEC	ICGC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1944
p.E263D	SIDM01611	Endometrial Carcinoma	GDSC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1944
p.E263D	ACH-000996	Endometrial/Uterine Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1944
p.T305S	TCGA-FD-A6TI	BLCA	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation blocking phosphorylation signal	0.6389
p.T305S	DO49764	BLCA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation blocking phosphorylation signal	0.6389
p.P303S	TCGA-GM-A2DO	BRCA	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.25
p.P303S	DO2037	BRCA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.25
p.D239E	TCGA-N5-A59E	UCS	TCGA	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.0833
p.P288H	TCGA-ZB-A961	THYM	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.2222
p.D294N	DO233101	GACA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation altering degron motif	0.5821
p.R147Q	DO13863	GBM	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.0833
p.D285Y	DO229027	LICA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.1389
p.M152I	DO229026	LICA	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.2222
p.C163F	DO229045	LICA	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.7108
p.N150Y	DO49875	LUAD	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1667
p.V161F	DO24800	LUAD	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.7068
p.L154M	DO50278	SKCM	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.2778
p.I170V	DO51783	STAD	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1389
p.L154P	DO229213	THCA	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.2778
p.E157K	DO52402	UCEC	ICGC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.7022
p.G240D	SIDM00282	Colorectal Carcinoma	GDSC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1111
p.G240D	ACH-000998	Colon/Colorectal Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1111
p.G240D	CW-2	large intestine	COSMIC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1111
p.T166S	SIDM00596	Endometrial Carcinoma	GDSC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.25
p.T166S	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.25
p.T166S	ACH-000954	Endometrial/Uterine Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.25
p.T166S	ACH-001517	Endometrial/Uterine Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.25
p.T166S	HEC-1	endometrium	COSMIC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.25
p.M260T	SIDM00100	Mesothelioma	GDSC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.2778
p.M260T	ACH-002127	Lung Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.2778
p.M260T	H2595	pleura	COSMIC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.2778
p.K254E	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.591
p.K254E	ROS-50	haematopoietic and lymphoid tissue	COSMIC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.591
p.R162K	SIDM00170	Head and Neck Carcinoma	GDSC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.6126
p.R162K	ACH-000682	Head and Neck Cancer	CCLE	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.6126
p.S249R	SIDM01611	Endometrial Carcinoma	GDSC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.7427
p.S249R	ACH-000996	Endometrial/Uterine Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation altering degron motif	0.7427
p.S305F	MDST8	large intestine	COSMIC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation blocking phosphorylation signal	0.6389
p.E264G	ETK-1	biliary tract	COSMIC	TSFELVKVPDP	DEG_COP1_1	248:258	Mutation rewiring degron network	0.1667
p.M155I	EMC-BAC-1	lung	COSMIC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.3056
p.Y308C	TE-4	oesophagus	COSMIC	TRDQLNIIV	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.1111
p.Y173D	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PTKTPGRT	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.0556

Kaplan plot for PIK3C3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3C3

UniProt ID: Q8NEB9

Entrez ID: 5289

Protein name: Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3C3 in