DegronMD

Uniprot ID: Q8NEB9

Source protein: Phosphatidylinositol 3-kinase catalytic subunit type 3

Source gene: PIK3C3

Class: DEG_COP1_1

Location: 248:258

E3 ligase: COP1

DEGRON score: 0.9734

ASA_SCORE: 49.1909

COIL: 0.6497

CONS_SCORE: 0.4281

DSS_SCORE: 0.4223

HELIX: 0.0899

FCONS_SCORE: 0.9631

RIG_SCORE: 0.8014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P256T	TCGA-C5-A8YQ	CESC	TCGA	TSFELVKVPDP	DEG_COP1_1	0.7031
p.E251K	TCGA-CD-A489	STAD	TCGA	TSFELVKVPDP	DEG_COP1_1	0.7022
p.P258L	TCGA-DA-A95Y	SKCM	TCGA	TSFELVKVPDP	DEG_COP1_1	0.6471
p.P245L	TCGA-EE-A20C	SKCM	TCGA	TSFELVKVPDP	DEG_COP1_1	0.25
p.E263D	TCGA-EY-A1GI	UCEC	TCGA	TSFELVKVPDP	DEG_COP1_1	0.1944
p.E263D	DO41211	UCEC	ICGC	TSFELVKVPDP	DEG_COP1_1	0.1944
p.E263D	SIDM01611	Endometrial Carcinoma	GDSC	TSFELVKVPDP	DEG_COP1_1	0.1944
p.E263D	ACH-000996	Endometrial/Uterine Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	0.1944
p.D239E	TCGA-N5-A59E	UCS	TCGA	TSFELVKVPDP	DEG_COP1_1	0.0833
p.G240D	SIDM00282	Colorectal Carcinoma	GDSC	TSFELVKVPDP	DEG_COP1_1	0.1111
p.G240D	ACH-000998	Colon/Colorectal Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	0.1111
p.G240D	CW-2	large_intestine	COSMIC	TSFELVKVPDP	DEG_COP1_1	0.1111
p.M260T	SIDM00100	Mesothelioma	GDSC	TSFELVKVPDP	DEG_COP1_1	0.2778
p.M260T	ACH-002127	Lung Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	0.2778
p.M260T	H2595	pleura	COSMIC	TSFELVKVPDP	DEG_COP1_1	0.2778
p.K254E	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	TSFELVKVPDP	DEG_COP1_1	0.591
p.K254E	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	TSFELVKVPDP	DEG_COP1_1	0.591
p.S249R	SIDM01611	Endometrial Carcinoma	GDSC	TSFELVKVPDP	DEG_COP1_1	0.7427
p.S249R	ACH-000996	Endometrial/Uterine Cancer	CCLE	TSFELVKVPDP	DEG_COP1_1	0.7427
p.E264G	ETK-1	biliary_tract	COSMIC	TSFELVKVPDP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	DEG_COP1_1	248:258	TSFELVKVPDP	COP1	0.9734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons