DegronMD

Uniprot ID: Q8NEB9

Source protein: Phosphatidylinositol 3-kinase catalytic subunit type 3

Source gene: PIK3C3

Class: DEG_APCC_DBOX_1

Location: 292:300

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9717

ASA_SCORE: 48.9667

COIL: 0.2198

CONS_SCORE: 0.5416

DSS_SCORE: 0.3915

HELIX: 0.5968

FCONS_SCORE: 1.0387

RIG_SCORE: 0.7943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A290T	TCGA-A5-A0G2	UCEC	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	0.2778
p.A290T	DO41235	UCEC	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.2778
p.S282Y	TCGA-BF-A1PZ	SKCM	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	0.5
p.S282Y	DO50279	SKCM	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.5
p.L296F	TCGA-EO-A22R	UCEC	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	0.6981
p.L296F	DO42713	UCEC	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.6981
p.T305S	TCGA-FD-A6TI	BLCA	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	0.6389
p.T305S	DO49764	BLCA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.6389
p.P303S	TCGA-GM-A2DO	BRCA	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	0.25
p.P303S	DO2037	BRCA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.25
p.P288H	TCGA-ZB-A961	THYM	TCGA	TRDQLNIIV	DEG_APCC_DBOX_1	0.2222
p.D294N	DO233101	GACA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.5821
p.D285Y	DO229027	LICA	ICGC	TRDQLNIIV	DEG_APCC_DBOX_1	0.1389
p.S305F	MDST8	large_intestine	COSMIC	TRDQLNIIV	DEG_APCC_DBOX_1	0.6389
p.Y308C	TE-4	oesophagus	COSMIC	TRDQLNIIV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	DEG_APCC_DBOX_1	292:300	TRDQLNIIV	APC,CDC20,FZR1	0.9717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons