DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1301:1308

E3 ligase: FBXW7

DEGRON score: 0.9857

ASA_SCORE: 100

COIL: 0.9603

CONS_SCORE: 0.4664

DSS_SCORE: 0.757

HELIX: 0.0131

FCONS_SCORE: 1.0751

RIG_SCORE: 0.5536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1312D	DO51017	LAML	ICGC	PTMTPDPT	DEG_SCF_FBW7_1	0.2222
p.Y1312H	DO229028	LICA	ICGC	PTMTPDPT	DEG_SCF_FBW7_1	0.2222
p.Y1312H	DO229031	LICA	ICGC	PTMTPDPT	DEG_SCF_FBW7_1	0.2222
p.P1305A	DO228231	MALY	ICGC	PTMTPDPT	DEG_SCF_FBW7_1	0.7503
p.D1306H	DO229268	THCA	ICGC	PTMTPDPT	DEG_SCF_FBW7_1	0.6577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1301:1308	PTMTPDPT	FBXW7	0.9857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons