DegronMD

Uniprot ID: Q86X53

Source protein: Glutamate-rich protein 1

Source gene: ERICH1

Class: DEG_SCF_FBW7_2

Location: 258:263

E3 ligase: FBXW7

DEGRON score: 0.9886

ASA_SCORE: 77.7167

COIL: 0.8678

CONS_SCORE: 0.2257

DSS_SCORE: 0.9043

HELIX: 0.0968

FCONS_SCORE: 1

RIG_SCORE: 0.5686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D268H	TCGA-68-8251	LUSC	TCGA	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.A269P	TCGA-85-8666	LUSC	TCGA	PTPAGE	DEG_SCF_FBW7_2	0.1667
p.A269P	DO45547	LUSC	ICGC	PTPAGE	DEG_SCF_FBW7_2	0.1667
p.G262R	TCGA-AY-6197	COAD	TCGA	PTPAGE	DEG_SCF_FBW7_2	0.6457
p.G262R	DO9956	COAD	ICGC	PTPAGE	DEG_SCF_FBW7_2	0.6457
p.T259I	TCGA-B5-A1MX	UCEC	TCGA	PTPAGE	DEG_SCF_FBW7_2	0.7078
p.P258L	TCGA-DM-A1D6	COAD	TCGA	PTPAGE	DEG_SCF_FBW7_2	0.6471
p.V266F	TCGA-DS-A7WF	CESC	TCGA	PTPAGE	DEG_SCF_FBW7_2	0.25
p.V266F	DO49922	CESC	ICGC	PTPAGE	DEG_SCF_FBW7_2	0.25
p.G261S	DO36969	READ	ICGC	PTPAGE	DEG_SCF_FBW7_2	0.6993
p.P260L	SIDM01198	Burkitt's Lymphoma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.7582
p.P260L	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAGE	DEG_SCF_FBW7_2	0.7582
p.A253T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.A253T	SIDM00309	Mesothelioma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.A253T	SIDM00808	Burkitt's Lymphoma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.A253T	SIDM01752	Pancreatic Carcinoma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.A253T	SIDM01254	Burkitt's Lymphoma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.A253T	ACH-000729	Lung Cancer	CCLE	PTPAGE	DEG_SCF_FBW7_2	0.1944
p.E249K	SIDM00699	Small Cell Lung Carcinoma	GDSC	PTPAGE	DEG_SCF_FBW7_2	0.0833
p.E249K	ACH-001138	Lung Cancer	CCLE	PTPAGE	DEG_SCF_FBW7_2	0.0833
p.E249K	NCI-H2141	lung	COSMIC	PTPAGE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86X53	Glutamate-rich protein 1	DEG_SCF_FBW7_2	258:263	PTPAGE	FBXW7	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons