DegronMD

Uniprot ID: Q9NRA0

Source protein: Sphingosine kinase 2

Source gene: SPHK2

Class: DEG_SCF_FBW7_1

Location: 388:393

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 76.95

COIL: 0.7837

CONS_SCORE: 0.3613

DSS_SCORE: 0.6008

HELIX: 0.1447

FCONS_SCORE: 1.073

RIG_SCORE: 0.6139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L387V	DO516	BLCA	ICGC	PTPAHS	DEG_SCF_FBW7_1	0.75
p.L387F	DO1663	BRCA	ICGC	PTPAHS	DEG_SCF_FBW7_1	0.75
p.D384E	DO23204	LINC	ICGC	PTPAHS	DEG_SCF_FBW7_1	0.2222
p.P402T	DO23364	LINC	ICGC	PTPAHS	DEG_SCF_FBW7_1	0.5278
p.L385V	SNU-175	large_intestine	COSMIC	PTPAHS	DEG_SCF_FBW7_1	0.25
p.G390V	SNU-1040	large_intestine	COSMIC	PTPAHS	DEG_SCF_FBW7_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRA0	Sphingosine kinase 2	DEG_SCF_FBW7_1	388:393	PTPAHS	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons