DegronMD - Q9NRA0(SPHK2)

SPHK2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R375H	TCGA-AX-A2HD	UCEC	TCGA	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.7133
p.P380H	TCGA-D3-A2JD	SKCM	TCGA	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6583
p.R373C	TCGA-ZF-AA4V	BLCA	TCGA	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.8301
p.R380H	DO219018	BLCA	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.8244
p.L387V	DO516	BLCA	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation blocking phosphorylation signal	0.5833
p.L387V	DO516	BLCA	ICGC	PTPAHS	DEG_SCF_FBW7_1	388:393	Mutation blocking phosphorylation signal	0.75
p.L387F	DO1663	BRCA	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation blocking phosphorylation signal	0.5833
p.L387F	DO1663	BRCA	ICGC	PTPAHS	DEG_SCF_FBW7_1	388:393	Mutation blocking phosphorylation signal	0.75
p.D368Y	DO44449	HNSC	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation blocking phosphorylation signal	0.6667
p.D384E	DO23204	LINC	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2222
p.D384E	DO23204	LINC	ICGC	PTPAHS	DEG_SCF_FBW7_1	388:393	Mutation rewiring degron network	0.2222
p.P402T	DO23364	LINC	ICGC	PTPAHS	DEG_SCF_FBW7_1	388:393	Mutation blocking phosphorylation signal	0.5278
p.L385V	SNU-175	large intestine	COSMIC	YRGRLSYLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1944
p.L385V	SNU-175	large intestine	COSMIC	PTPAHS	DEG_SCF_FBW7_1	388:393	Mutation rewiring degron network	0.25
p.G390V	SNU-1040	large intestine	COSMIC	PTPAHS	DEG_SCF_FBW7_1	388:393	Mutation altering degron motif	0.7532

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*NOTE: the Kaplan plots were collected from OncoLnc