DegronMD

Uniprot ID: Q9NRA0

Source protein: Sphingosine kinase 2

Source gene: SPHK2

Class: DEG_APCC_DBOX_1

Location: 372:380

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9587

ASA_SCORE: 34.5778

COIL: 0.1432

CONS_SCORE: 0.6232

DSS_SCORE: 0.2506

HELIX: 0.0086

FCONS_SCORE: 1.4551

RIG_SCORE: 0.7852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R375H	TCGA-AX-A2HD	UCEC	TCGA	YRGRLSYLP	DEG_APCC_DBOX_1	0.7133
p.P380H	TCGA-D3-A2JD	SKCM	TCGA	YRGRLSYLP	DEG_APCC_DBOX_1	0.6583
p.R373C	TCGA-ZF-AA4V	BLCA	TCGA	YRGRLSYLP	DEG_APCC_DBOX_1	0.8301
p.R380H	DO219018	BLCA	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	0.8244
p.L387V	DO516	BLCA	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	0.5833
p.L387F	DO1663	BRCA	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	0.5833
p.D368Y	DO44449	HNSC	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	0.6667
p.D384E	DO23204	LINC	ICGC	YRGRLSYLP	DEG_APCC_DBOX_1	0.2222
p.L385V	SNU-175	large_intestine	COSMIC	YRGRLSYLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRA0	Sphingosine kinase 2	DEG_APCC_DBOX_1	372:380	YRGRLSYLP	APC,CDC20,FZR1	0.9587	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons