DegronMD

Uniprot ID: P0C7H8

Source protein: Keratin-associated protein 2-3

Source gene: KRTAP2-3

Class: DEG_SCF_FBW7_1

Location: 116:121

E3 ligase: FBXW7

DEGRON score: 0.8341

ASA_SCORE: 76.4333

COIL: 0.8538

CONS_SCORE: 0.2555

DSS_SCORE: 0.0006

HELIX: 0.0165

FCONS_SCORE: 0.5277

RIG_SCORE: 0.7048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P116L	TCGA-FI-A2D5	UCEC	TCGA	PTPCST	DEG_SCF_FBW7_1	0.6471
p.P116L	DO41331	UCEC	ICGC	PTPCST	DEG_SCF_FBW7_1	0.6471
p.P107S	DO220857	MELA	ICGC	PTPCST	DEG_SCF_FBW7_1	0.0833
p.P112S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PTPCST	DEG_SCF_FBW7_1	0.2222
p.C128F	ACH-001193	Bone Cancer	CCLE	PTPCST	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons