DegronMD

Uniprot ID: Q9BYR9

Source protein: Keratin-associated protein 2-4

Source gene: KRTAP2-4

Class: DEG_SCF_FBW7_1

Location: 116:121

E3 ligase: FBXW7

DEGRON score: 0.8341

ASA_SCORE: 76.4333

COIL: 0.8538

CONS_SCORE: 0.2554

DSS_SCORE: 0.0006

HELIX: 0.0165

FCONS_SCORE: 0.5275

RIG_SCORE: 0.7048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C123Y	TCGA-AJ-A3OL	UCEC	TCGA	PTPCST	DEG_SCF_FBW7_1	0.2778
p.C123Y	DO43001	UCEC	ICGC	PTPCST	DEG_SCF_FBW7_1	0.2778
p.T121I	TCGA-FF-8043	DLBC	TCGA	PTPCST	DEG_SCF_FBW7_1	0.7078
p.T121I	DO222308	DLBC	ICGC	PTPCST	DEG_SCF_FBW7_1	0.7078
p.C128G	DO222736	BTCA	ICGC	PTPCST	DEG_SCF_FBW7_1	0.1389
p.P118H	DO10324	COAD	ICGC	PTPCST	DEG_SCF_FBW7_1	0.7694
p.R110W	DO227802	COCA	ICGC	PTPCST	DEG_SCF_FBW7_1	0.1667
p.C109G	SIDM00667	Other Sarcomas	GDSC	PTPCST	DEG_SCF_FBW7_1	0.1389
p.R124M	ACH-000399	Lung Cancer	CCLE	PTPCST	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons