DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPENT
Uniprot ID:
Q9H6A9
Source protein:
Pecanex-like protein 3
Source gene:
PCNX3
Class:
DEG_SCF_FBW7_1
Location:
1858:1863
E3 ligase:
FBXW7
DEGRON score:
0.8976
ASA_SCORE:
101.5667
COIL:
0.9467
CONS_SCORE:
0.3332
DSS_SCORE:
0.8091
HELIX:
0.02
FCONS_SCORE:
0.9801
RIG_SCORE:
0.6062
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D1868N
SIDM00770
Small Cell Lung Carcinoma
GDSC
PTPENT
DEG_SCF_FBW7_1
0.1944
p.D1868N
NCI-H1836
lung
COSMIC
PTPENT
DEG_SCF_FBW7_1
0.1944
Drug responses associated with PCNX3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPENT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6A9
Pecanex-like protein 3
DEG_SCF_FBW7_1
1858:1863
PTPENT
FBXW7
0.8976
More...