DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 3534:3539

E3 ligase: FBXW7

DEGRON score: 0.5578

ASA_SCORE: 86.05

COIL: 0.8827

CONS_SCORE: 0

DSS_SCORE: 0.491

HELIX: 0.0135

FCONS_SCORE: 0

RIG_SCORE: 0.701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3535A	TCGA-BH-A18G	BRCA	TCGA	PTPGIS	DEG_SCF_FBW7_1	0.7139
p.T3535A	DO3686	BRCA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.7139
p.G3546E	TCGA-EE-A2MS	SKCM	TCGA	PTPGIS	DEG_SCF_FBW7_1	0.1389
p.G3546E	DO37567	SKCM	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.1389
p.P3536S	TCGA-EE-A2MS	SKCM	TCGA	PTPGIS	DEG_SCF_FBW7_1	0.6752
p.P3536S	DO37567	SKCM	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.6752
p.T3532A	TCGA-FI-A2D5	UCEC	TCGA	PTPGIS	DEG_SCF_FBW7_1	0.2778
p.T3532A	DO41331	UCEC	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2778
p.E3524K	TCGA-LI-A67I	SARC	TCGA	PTPGIS	DEG_SCF_FBW7_1	0.0556
p.E3524K	DO220201	SARC	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.0556
p.D3529N	TCGA-QR-A6GW	PCPG	TCGA	PTPGIS	DEG_SCF_FBW7_1	0.1944
p.V3530I	DO222990	BTCA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.V3530I	DO230334	COCA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.V3530I	DO229013	COCA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.V3530I	DO229505	LAML	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.V3530I	DO228941	LICA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.V3530I	DO231102	LUSC	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.S3539T	DO234353	ESAD	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.6005
p.D3529Y	DO231047	LUSC	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.1944
p.G3546R	DO222749	MELA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.1389
p.P3536L	DO51482	PACA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.7582
p.P3536Q	DO228141	PBCA	ICGC	PTPGIS	DEG_SCF_FBW7_1	0.7035
p.T3544I	SIDM01134	Small Cell Lung Carcinoma	GDSC	PTPGIS	DEG_SCF_FBW7_1	0.1944
p.T3544I	ACH-000292	Lung Cancer	CCLE	PTPGIS	DEG_SCF_FBW7_1	0.1944
p.T3544I	NCI-H841	lung	COSMIC	PTPGIS	DEG_SCF_FBW7_1	0.1944
p.T3543I	SIDM00225	Melanoma	GDSC	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.T3543I	ACH-002143	Skin Cancer	CCLE	PTPGIS	DEG_SCF_FBW7_1	0.2222
p.T3543I	IST-MEL1	skin	COSMIC	PTPGIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	3534:3539	PTPGIS	FBXW7	0.5578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPGIS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PTPGIS