DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PTPGKS
Uniprot ID:
Q7Z6P3
Source protein:
Ras-related protein Rab-44
Source gene:
RAB44
Class:
DEG_SCF_FBW7_1
Location:
734:739
E3 ligase:
FBXW7
DEGRON score:
0.9001
ASA_SCORE:
89.5167
COIL:
0.9475
CONS_SCORE:
0
DSS_SCORE:
0.8725
HELIX:
0.0135
FCONS_SCORE:
0
RIG_SCORE:
0.4887
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V737A
DO225083
BRCA
ICGC
PTPGKS
DEG_SCF_FBW7_1
0.6936
p.V737M
DO218728
GACA
ICGC
PTPGKS
DEG_SCF_FBW7_1
0.7208
Drug responses associated with RAB44 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPGKS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z6P3
Ras-related protein Rab-44
DEG_SCF_FBW7_1
734:739
PTPGKS
FBXW7
0.9001
More...