DegronMD

Uniprot ID: O75023

Source protein: Leukocyte immunoglobulin-like receptor subfamily B member 5

Source gene: LILRB5

Class: DEG_SCF_FBW7_2

Location: 433:438

E3 ligase: FBXW7

DEGRON score: 0.788

ASA_SCORE: 70.85

COIL: 0.9037

CONS_SCORE: 0.3285

DSS_SCORE: 0.8547

HELIX: 0.063

FCONS_SCORE: 1.2114

RIG_SCORE: 0.5203

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P438H	TCGA-21-1082	LUSC	TCGA	PTPGPE	DEG_SCF_FBW7_2	0.7694
p.P438H	DO26463	LUSC	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.7694
p.D423Y	TCGA-DX-A8BV	SARC	TCGA	PTPGPE	DEG_SCF_FBW7_2	0.0556
p.D423Y	DO220066	SARC	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.0556
p.L425P	DO8264	COAD	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1111
p.R443P	DO229003	COCA	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1944
p.R443P	DO229005	COCA	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1944
p.R443P	DO231102	LUSC	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1944
p.G430C	DO228542	GACA	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.25
p.T444N	DO232666	PBCA	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1667
p.L425I	DO36881	READ	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1111
p.A428D	DO229216	THCA	ICGC	PTPGPE	DEG_SCF_FBW7_2	0.1944
p.P444L	ACH-000969	Colon/Colorectal Cancer	CCLE	PTPGPE	DEG_SCF_FBW7_2	0.1667
p.A446S	AU565	breast	COSMIC	PTPGPE	DEG_SCF_FBW7_2	0.1111
p.T432I	LN-18	central_nervous_system	COSMIC	PTPGPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75023	Leukocyte immunoglobulin-like receptor subfamily B member 5	DEG_SCF_FBW7_2	433:438	PTPGPE	FBXW7	0.788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons