DegronMD

Uniprot ID: O00754

Source protein: Lysosomal alpha-mannosidase

Source gene: MAN2B1

Class: DEG_SCF_FBW7_1

Location: 976:981

E3 ligase: FBXW7

DEGRON score: 0.5712

ASA_SCORE: 90.8667

COIL: 0.9102

CONS_SCORE: 0.2918

DSS_SCORE: 0.5896

HELIX: 0.021

FCONS_SCORE: 0.7999

RIG_SCORE: 0.6661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S966Y	TCGA-AP-A059	UCEC	TCGA	PTPHQT	DEG_SCF_FBW7_1	0.0556
p.S966Y	DO41361	UCEC	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.0556
p.W970L	TCGA-B5-A11E	UCEC	TCGA	PTPHQT	DEG_SCF_FBW7_1	0.1667
p.W970L	DO41644	UCEC	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.1667
p.P987L	TCGA-DA-A1I0	SKCM	TCGA	PTPHQT	DEG_SCF_FBW7_1	0.1667
p.P987L	DO37719	SKCM	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.1667
p.A988T	TCGA-EY-A1GI	UCEC	TCGA	PTPHQT	DEG_SCF_FBW7_1	0.1389
p.A988T	DO41211	UCEC	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.1389
p.N973H	TCGA-IR-A3LI	CESC	TCGA	PTPHQT	DEG_SCF_FBW7_1	0.25
p.N973H	DO44400	CESC	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.25
p.N989S	DO233259	GACA	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.1111
p.P987T	DO228198	LICA	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.1667
p.Q980K	DO229028	LICA	ICGC	PTPHQT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00754	Lysosomal alpha-mannosidase	DEG_SCF_FBW7_1	976:981	PTPHQT	FBXW7	0.5712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons