DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 1161:1166

E3 ligase: FBXW7

DEGRON score: 0.9111

ASA_SCORE: 98.0333

COIL: 0.9015

CONS_SCORE: 0

DSS_SCORE: 0.5612

HELIX: 0.0188

FCONS_SCORE: 0

RIG_SCORE: 0.6308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1157Y	TCGA-AA-3977	COAD	TCGA	PTPKVT	DEG_SCF_FBW7_1	0.2222
p.S1157Y	DO8730	COAD	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.2222
p.P1161S	TCGA-BF-A1PX	SKCM	TCGA	PTPKVT	DEG_SCF_FBW7_1	0.6752
p.P1161S	DO51236	SKCM	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.6752
p.G1152D	TCGA-CA-5256	COAD	TCGA	PTPKVT	DEG_SCF_FBW7_1	0.0833
p.G1152D	DO10526	COAD	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.0833
p.S1172L	TCGA-D9-A6EA	SKCM	TCGA	PTPKVT	DEG_SCF_FBW7_1	0.1667
p.S1172L	DO50290	SKCM	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.1667
p.S1157F	TCGA-MY-A913	CESC	TCGA	PTPKVT	DEG_SCF_FBW7_1	0.2222
p.S1157F	DO49980	CESC	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.2222
p.P1163S	TCGA-YG-AA3O	SKCM	TCGA	PTPKVT	DEG_SCF_FBW7_1	0.6752
p.P1163S	DO51299	SKCM	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.6752
p.F1171S	DO6540	CLLE	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.1944
p.T1162I	DO229010	COCA	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.T1162I	DO229016	COCA	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.T1162I	DO229003	COCA	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.T1162I	DO229005	COCA	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.T1162I	DO234205	ESAD	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.T1162I	DO234285	ESAD	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.T1162I	DO52365	LUSC	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.7078
p.L1154V	DO234233	ESAD	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.1389
p.L1154V	DO228761	GACA	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.1389
p.L1154V	DO233718	GACA	ICGC	PTPKVT	DEG_SCF_FBW7_1	0.1389
p.T1162A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTPKVT	DEG_SCF_FBW7_1	0.7139
p.T1162A	ACH-002256	Leukemia	CCLE	PTPKVT	DEG_SCF_FBW7_1	0.7139
p.T1162A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTPKVT	DEG_SCF_FBW7_1	0.7139
p.P1161A	ACH-000975	Lung Cancer	CCLE	PTPKVT	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	1161:1166	PTPKVT	FBXW7	0.9111	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPKVT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PTPKVT