DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPLST
Uniprot ID:
Q6AHZ1
Source protein:
Zinc finger protein 518A
Source gene:
ZNF518A
Class:
DEG_SCF_FBW7_1
Location:
393:398
E3 ligase:
FBXW7
DEGRON score:
0.9978
ASA_SCORE:
71.05
COIL:
0.7205
CONS_SCORE:
0.4726
DSS_SCORE:
0.8105
HELIX:
0.019
FCONS_SCORE:
1.0895
RIG_SCORE:
0.5858
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S390L
SIDM01608
Endometrial Carcinoma
GDSC
PTPLST
DEG_SCF_FBW7_1
0.25
Drug responses associated with ZNF518A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPLST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6AHZ1
Zinc finger protein 518A
DEG_SCF_FBW7_1
393:398
PTPLST
FBXW7
0.9978
More...