DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SCF_FBW7_2

Location: 1130:1135

E3 ligase: FBXW7

DEGRON score: 0.9124

ASA_SCORE: 95.6667

COIL: 0.8183

CONS_SCORE: 0.5821

DSS_SCORE: 0.8206

HELIX: 0.1322

FCONS_SCORE: 1.0447

RIG_SCORE: 0.6176

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1127Y	TCGA-4Z-AA7M	BLCA	TCGA	PTPMDE	DEG_SCF_FBW7_2	0.25
p.S1127Y	DO218976	BLCA	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.25
p.S1127T	TCGA-AA-3811	COAD	TCGA	PTPMDE	DEG_SCF_FBW7_2	0.25
p.S1127T	DO7962	COAD	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.25
p.E1129K	TCGA-DK-A2I4	BLCA	TCGA	PTPMDE	DEG_SCF_FBW7_2	0.3056
p.E1129K	DO465	BLCA	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.3056
p.P1132H	TCGA-EE-A2GH	SKCM	TCGA	PTPMDE	DEG_SCF_FBW7_2	0.7694
p.P1132H	DO37643	SKCM	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.7694
p.P1139R	TCGA-UY-A8OB	BLCA	TCGA	PTPMDE	DEG_SCF_FBW7_2	0.2222
p.P1139R	DO219037	BLCA	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.2222
p.V1142M	DO230347	COCA	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.1389
p.V1142L	DO229028	LICA	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.1389
p.M1133I	DO220907	MELA	ICGC	PTPMDE	DEG_SCF_FBW7_2	0.6507
p.D1134N	ACH-001568	Skin Cancer	CCLE	PTPMDE	DEG_SCF_FBW7_2	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SCF_FBW7_2	1130:1135	PTPMDE	FBXW7	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons