DegronMD

Uniprot ID: Q9BZM2

Source protein: Group IIF secretory phospholipase A2

Source gene: PLA2G2F

Class: DEG_SCF_FBW7_1

Location: 141:146

E3 ligase: FBXW7

DEGRON score: 0.5761

ASA_SCORE: 77.8833

COIL: 0.9328

CONS_SCORE: 0.5068

DSS_SCORE: 0.2173

HELIX: 0.0133

FCONS_SCORE: 1.1276

RIG_SCORE: 0.6971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C154Y	TCGA-22-5478	LUSC	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.1111
p.C154Y	DO27011	LUSC	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.1111
p.C156Y	TCGA-AX-A2HA	UCEC	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.0556
p.C156Y	DO42504	UCEC	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.0556
p.E134K	TCGA-EB-A431	SKCM	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.1389
p.E134K	DO37671	SKCM	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.1389
p.E138D	TCGA-EY-A1GS	UCEC	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.25
p.E138D	DO43162	UCEC	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.25
p.H131D	TCGA-JW-A5VL	CESC	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.0556
p.H131D	DO49976	CESC	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.0556
p.T147S	TCGA-VQ-A8PT	STAD	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.3056
p.T147S	DO51776	STAD	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.3056
p.E138K	TCGA-WE-A8K6	SKCM	TCGA	PTPNCS	DEG_SCF_FBW7_1	0.25
p.E138K	DO51283	SKCM	ICGC	PTPNCS	DEG_SCF_FBW7_1	0.25
p.I133F	SIDM01175	Other Sarcomas	GDSC	PTPNCS	DEG_SCF_FBW7_1	0.1111
p.I133F	ACH-002309	Sarcoma	CCLE	PTPNCS	DEG_SCF_FBW7_1	0.1111
p.I133F	SW684	soft_tissue	COSMIC	PTPNCS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZM2	Group IIF secretory phospholipase A2	DEG_SCF_FBW7_1	141:146	PTPNCS	FBXW7	0.5761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons