DegronMD

Uniprot ID: Q92858

Source protein: Transcription factor ATOH1

Source gene: ATOH1

Class: DEG_SCF_FBW7_1

Location: 266:271

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 63.6667

COIL: 0.9253

CONS_SCORE: 0.3116

DSS_SCORE: 0.6704

HELIX: 0.026

FCONS_SCORE: 1.0929

RIG_SCORE: 0.591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q258K	TCGA-86-8585	LUAD	TCGA	PTPPGS	DEG_SCF_FBW7_1	0.1111
p.Q258K	DO24850	LUAD	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.1111
p.A256T	TCGA-A8-A06X	BRCA	TCGA	PTPPGS	DEG_SCF_FBW7_1	0.0556
p.A256T	DO5074	BRCA	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.0556
p.A278T	TCGA-B5-A11H	UCEC	TCGA	PTPPGS	DEG_SCF_FBW7_1	0.1389
p.A278T	DO227646	COCA	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.1389
p.A278T	DO42825	UCEC	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.1389
p.A278V	TCGA-FI-A2D4	UCEC	TCGA	PTPPGS	DEG_SCF_FBW7_1	0.1389
p.A278V	DO43170	UCEC	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.1389
p.S281F	DO234338	ESAD	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.0556
p.R273L	DO229025	LICA	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.2778
p.R273Q	DO218863	SKCA	ICGC	PTPPGS	DEG_SCF_FBW7_1	0.2778
p.G270R	SIDM01117	Small Cell Lung Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457
p.G270R	SIDM00633	Breast Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457
p.G270R	SIDM01039	Other Solid Cancers	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457
p.G270R	SIDM01140	Ovarian Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457
p.G270R	SIDM00808	Burkitt's Lymphoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457
p.G270R	SIDM01318	Hepatocellular Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457
p.G270R	SIDM01254	Burkitt's Lymphoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92858	Transcription factor ATOH1	DEG_SCF_FBW7_1	266:271	PTPPGS	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons