DegronMD - Q92858(ATOH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q258K	TCGA-86-8585	LUAD	TCGA	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1111
p.Q258K	DO24850	LUAD	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1111
p.R125Q	TCGA-97-7547	LUAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	DO23594	LUAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.A256T	TCGA-A8-A06X	BRCA	TCGA	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.0556
p.A256T	DO5074	BRCA	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.0556
p.A278T	TCGA-B5-A11H	UCEC	TCGA	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1389
p.A278T	DO227646	COCA	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1389
p.A278T	DO42825	UCEC	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1389
p.R125W	TCGA-BR-A4QL	STAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8634
p.R125W	DO38723	STAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8634
p.R125W	DO229257	THCA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8634
p.V122L	TCGA-CC-A5UC	LIHC	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778
p.V122L	DO52173	LIHC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778
p.S115G	TCGA-CG-5726	STAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.S115G	DO38483	STAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.G133R	TCGA-CR-7388	HNSC	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.G133R	DO14284	HNSC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.V136A	TCGA-D1-A15X	UCEC	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.V136A	DO43274	UCEC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.E126K	TCGA-D3-A51T	SKCM	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.591
p.E126K	DO47389	SKCM	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.591
p.V136L	TCGA-E7-A5KE	BLCA	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.V136L	DO44048	BLCA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.K130N	TCGA-ER-A3ET	SKCM	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5806
p.K130N	DO37459	SKCM	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5806
p.A278V	TCGA-FI-A2D4	UCEC	TCGA	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1389
p.A278V	DO43170	UCEC	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.1389
p.D138Y	TCGA-KV-A74V	KIRP	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138Y	DO48480	KIRP	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.L128V	TCGA-WS-AB45	COAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.6765
p.L128V	DO51734	COAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.6765
p.S281F	DO234338	ESAD	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.0556
p.C129S	DO233900	GACA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.643
p.R273L	DO229025	LICA	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.2778
p.G120V	DO229036	LICA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.R273Q	DO218863	SKCA	ICGC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation rewiring degron network	0.2778
p.P119H	DO42673	UCEC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1944
p.D138E	SIDM01265	Plasma Cell Myeloma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00973	Melanoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00690	Head and Neck Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00694	Other Solid Cancers	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00254	Neuroblastoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00309	Mesothelioma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00844	Burkitt's Lymphoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM00673	Breast Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.D138E	SIDM01752	Pancreatic Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.G270R	SIDM01117	Small Cell Lung Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457
p.G270R	SIDM00633	Breast Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457
p.G270R	SIDM01039	Other Solid Cancers	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457
p.G270R	SIDM01140	Ovarian Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457
p.G270R	SIDM00808	Burkitt's Lymphoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457
p.G270R	SIDM01318	Hepatocellular Carcinoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457
p.G270R	SIDM01254	Burkitt's Lymphoma	GDSC	PTPPGS	DEG_SCF_FBW7_1	266:271	Mutation altering degron motif	0.6457

Kaplan plot for ATOH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATOH1

UniProt ID: Q92858

Entrez ID: 474

Protein name: Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATOH1 in