DegronMD

Uniprot ID: Q92858

Source protein: Transcription factor ATOH1

Source gene: ATOH1

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5975

ASA_SCORE: 103.0222

COIL: 0.4768

CONS_SCORE: 0.4354

DSS_SCORE: 0.3988

HELIX: 0.4884

FCONS_SCORE: 1.1225

RIG_SCORE: 0.7973

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R125Q	TCGA-97-7547	LUAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.7329
p.R125Q	DO23594	LUAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.7329
p.R125W	TCGA-BR-A4QL	STAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.8634
p.R125W	DO38723	STAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.8634
p.R125W	DO229257	THCA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.8634
p.V122L	TCGA-CC-A5UC	LIHC	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.2778
p.V122L	DO52173	LIHC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.2778
p.S115G	TCGA-CG-5726	STAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.0833
p.S115G	DO38483	STAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.0833
p.G133R	TCGA-CR-7388	HNSC	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.3056
p.G133R	DO14284	HNSC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.3056
p.V136A	TCGA-D1-A15X	UCEC	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.2222
p.V136A	DO43274	UCEC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.2222
p.E126K	TCGA-D3-A51T	SKCM	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.591
p.E126K	DO47389	SKCM	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.591
p.V136L	TCGA-E7-A5KE	BLCA	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.2222
p.V136L	DO44048	BLCA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.2222
p.K130N	TCGA-ER-A3ET	SKCM	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.5806
p.K130N	DO37459	SKCM	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.5806
p.D138Y	TCGA-KV-A74V	KIRP	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138Y	DO48480	KIRP	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.L128V	TCGA-WS-AB45	COAD	TCGA	VREQLCKLK	DEG_APCC_DBOX_1	0.6765
p.L128V	DO51734	COAD	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.6765
p.C129S	DO233900	GACA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.643
p.G120V	DO229036	LICA	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.2222
p.P119H	DO42673	UCEC	ICGC	VREQLCKLK	DEG_APCC_DBOX_1	0.1944
p.D138E	SIDM01265	Plasma Cell Myeloma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00973	Melanoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00690	Head and Neck Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00694	Other Solid Cancers	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00254	Neuroblastoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00309	Mesothelioma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00844	Burkitt's Lymphoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM00673	Breast Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667
p.D138E	SIDM01752	Pancreatic Carcinoma	GDSC	VREQLCKLK	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VREQLCKLK

Degron related mutations and impact score

Drug responses associated with ATOH1 mutations

All proteins holding degron of VREQLCKLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92858	Transcription factor ATOH1	DEG_APCC_DBOX_1	124:132	VREQLCKLK	APC,CDC20,FZR1	0.5975	More...