DegronMD

Uniprot ID: O15117

Source protein: FYN-binding protein 1

Source gene: FYB1

Class: DEG_SCF_FBW7_1

Location: 157:162

E3 ligase: FBXW7

DEGRON score: 0.939

ASA_SCORE: 81.6667

COIL: 0.918

CONS_SCORE: 0.4293

DSS_SCORE: 0.8387

HELIX: 0.0697

FCONS_SCORE: 0.7943

RIG_SCORE: 0.5397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P163L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PTPPTS	DEG_SCF_FBW7_1	0.3056
p.P163L	NCI-H1563	lung	COSMIC	PTPPTS	DEG_SCF_FBW7_1	0.3056
p.P147L	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	PTPPTS	DEG_SCF_FBW7_1	0.0556
p.P153L	NCI-H1563	lung	COSMIC	PTPPTS	DEG_SCF_FBW7_1	0.2222
p.A169V	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPTS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SCF_FBW7_1	157:162	PTPPTS	FBXW7	0.939	More...
P49716	CCAAT/enhancer-binding protein delta	DEG_SCF_FBW7_1	155:160	PTPPTS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons