DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPPTS
Uniprot ID:
P49716
Source protein:
CCAAT/enhancer-binding protein delta
Source gene:
CEBPD
Class:
DEG_SCF_FBW7_1
Location:
155:160
E3 ligase:
FBXW7
DEGRON score:
0.9974
ASA_SCORE:
88.6667
COIL:
0.9772
CONS_SCORE:
0.5978
DSS_SCORE:
0.7934
HELIX:
0.006
FCONS_SCORE:
1.3359
RIG_SCORE:
0.5122
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R169G
SIDM00266
Ewing's Sarcoma
GDSC
PTPPTS
DEG_SCF_FBW7_1
0.0833
p.R165H
SIDM00951
T-Lymphoblastic Leukemia
GDSC
PTPPTS
DEG_SCF_FBW7_1
0.1944
Drug responses associated with CEBPD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPPTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15117
FYN-binding protein 1
DEG_SCF_FBW7_1
157:162
PTPPTS
FBXW7
0.939
More...
P49716
CCAAT/enhancer-binding protein delta
DEG_SCF_FBW7_1
155:160
PTPPTS
FBXW7
0.9974
More...